Heart Valves

Author: Paul A. Iaizzo
Publisher: Springer Science & Business Media
ISBN: 1461461448
Format: PDF, ePub, Docs
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Cardiovascular disease is the major cause of morbidity and mortality worldwide. While the past 40 years have brought major progress in cardiac valve repair and replacement, there remain large patient populations that do not receive such therapies. This, in turn, implies a great need for future basic, applied, and clinical research and, ultimately, therapeutic developments. Heart Valves is a state-of-the-art handbook dedicated to: 1) cardiac valve anatomy, 2) models for testing and research methods; 3) clinical trials; and 4) clinical needs and applications.

Transcatheter Valve Therapies

Author: Christoph Huber
Publisher: CRC Press
ISBN: 1439810826
Format: PDF, Kindle
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The landscape of cardiac surgery is changing, as is the field of interventional cardiology. The idea of accessing and replacing a failing valve through the patients vasculature has become the most rapidly expanding therapy of choice in cardiovascular disease. Transcatheter Valve Therapies chronicles the astonishing advances that have taken place in the field and prepares readers for the challenging future of cardiac valve therapies. Designed to meet the growing needs of cardiologists, cardiac surgeons, anesthetists, and general practitioners, the book covers all aspects from logistic needs to clinical outcomes. It provides a comprehensive overview of transcatheter valve therapies and the necessary understanding for a successful clinical introduction at individual institutions. Topics include: Epidemiologic considerations Aspects of balloon aortic valvuloplasty as a stand-alone procedure or as part of the transcatheter valve replacement The history of how transcatheter valve therapies were implemented into surgical practice New imaging modalities The particularities of transcatheter access Aortic root anatomy Emerging technologies and future design improvements Development steps of aortic devices and potential solutions for transcatheter tricuspid, mitral, and pulmonary valve replacement The rigorous testing requirements for endovascular medical devices Clinical results of aortic transcatheter valve therapies in easy accessible text and table formats The future of transcatheter valve therapies All topics are discussed based on the author’s own clinical and experimental experience in the field. This volume is essential for anyone involved in transcatheter valve implantation, clinicians wishing to become more involved in improving transcatheter valve therapies, and researchers engaged in building and creating new medical technologies to shape the cardiovascular landscape of the future.

Cardiac Reconstructions with Allograft Tissues

Author: Richard A. Hopkins
Publisher: Springer Science & Business Media
ISBN: 0387265155
Format: PDF, Docs
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Cryopreserved allograft tissues are now standard materials for the reconstructive cardiac surgeon. Since publication of the first edition ("Cardiac Reconstructions with Allograft Valves") in 1989, the field has progressed dramatically with increased clinical use of cardiovascular allograft tissues, with the development of new surgical techniques, and with advances in the understanding of the fundamentals of valve transplantation biology and cryopreservation. As a result, over two-thirds of the present volume represents new material. Fifty-six authors bring their expertise to thirteen comprehensive, lavishly illustrated sections which discuss the principles of the use of homograft valves, major clinical series of homograft valves for both left and right ventricular outflow tracts, cryopreserved allograft tissue for cardiac reconstruction, cell biology of heart valve leaflets, cryobiology of heart valve preservation, morphological, biochemical, and explant pathology studies of allograft heart valves, allograft valve banking, as well as detailed explanation of surgical techniques for valve and root methods for left and right ventricular outflow tract reconstructions, the Ross operation and variants, and complex reconstructions. A final section presents potential future directions for the field. Over 400 illustrations, created expressly for this book, depict the surgical techniques from the perspective of the surgeon standing at the operating table. All surgeons performing pediatric and/or adult valve replacements and reconstructive cardiac surgeries will benefit from the described methods. Cardiothoracic residents and cardiologists will also find the text useful. It will provide the surgeon with an enhanced understanding of the biological and material properties of allografts and increased familiarity with the range of surgical techniques applicable for the use of these valves, particularly in the successful management of challenging cardiac reconstructions.>

Handbook of Cardiac Stem Cell Therapy

Author: Ioannis Dimarakis
Publisher: World Scientific
ISBN: 1848162561
Format: PDF, Kindle
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This book is an impressive compilation of contributions on the hot topic of cardiac stem cell therapy from leading groups all over the world. In the assembly of chapters, a structured approach is adopted; starting from the clinician's perspective, all developments in both the experimental and clinical research areas are covered. This journey will take the reader from the bench-top to the bedside, with all chapters written by leading authorities in their respective fields, including data still in press with medical journals. So, beyond being excellent as an overall update for scientists in the field of cardiac stem cell therapy, this book will likely prove an indispensable tool for every budding scientist considering a research project within this field.

Transcatheter Valve Repair

Author: Ziyad M. Hijazi
Publisher: CRC Press
ISBN: 9781841844725
Format: PDF, ePub, Mobi
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Transcatheter Valve Repair discusses all aspects related to percutaneous and established valve repair methods. The book is divided into few major sections covering all four valves and other topics. Each section contains several chapters discussing everything related to that valve. Beginning with the pulmonary valve, since it was the first valve to be tackled in the catheterization laboratory, and then moving to the aortic, then the mitral and then finally end with the tricuspid valve. 1.5M US citizens alone have some degree of aortic valve stenosis, with half (750K) requiring aortic valve replacement. Aortic valve replacement, on the whole, is performed by surgeons, requiring bypass machines and technicians, as well as the usual operating team. The operation is expensive and occupies a considerable amount of operating room time. Mostly, the aortic valve is calcified and the usual option available to patients is valve replacement with a variety of choices, ranging from porcine valves to synthetic, for which there are many manufacturers. It should be noted that the aortic valve is the most problematic of valves. Percutaneous procedures are the answer. The bottom line is that given the growing elderly population, many more patients will require valve repair, thus increasing health care costs with not only surgical operations but also hospitalisation. Percutanous valve repair, whilst requiring a cath lab team, does not involve bypass machines nor extended hospitalisation. Like percutaneous transluminal coronary artery interventions (PTCA) has replaced coronary artery bypass grafts (once the golden standard), and now stenting having replaced PTCA and its balloons. We now see drug eluting stents replacing ordinary stents (though at a much higher cost. There will be a huge movement toward percutanous valve repair, which should presumably cut costs but also morbidity and mortality.

Comprehensive Biomaterials

Author: Paul Ducheyne
Publisher: Elsevier
ISBN: 0080552943
Format: PDF, ePub
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Comprehensive Biomaterials brings together the myriad facets of biomaterials into one, major series of six edited volumes that would cover the field of biomaterials in a major, extensive fashion: Volume 1: Metallic, Ceramic and Polymeric Biomaterials Volume 2: Biologically Inspired and Biomolecular Materials Volume 3: Methods of Analysis Volume 4: Biocompatibility, Surface Engineering, and Delivery Of Drugs, Genes and Other Molecules Volume 5: Tissue and Organ Engineering Volume 6: Biomaterials and Clinical Use Experts from around the world in hundreds of related biomaterials areas have contributed to this publication, resulting in a continuum of rich information appropriate for many audiences. The work addresses the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, and strategic insights for those entering and operational in diverse biomaterials applications, research and development, regulatory management, and commercial aspects. From the outset, the goal was to review materials in the context of medical devices and tissue properties, biocompatibility and surface analysis, tissue engineering and controlled release. It was also the intent both, to focus on material properties from the perspectives of therapeutic and diagnostic use, and to address questions relevant to state-of-the-art research endeavors. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance as well as future prospects Presents appropriate analytical methods and testing procedures in addition to potential device applications Provides strategic insights for those working on diverse application areas such as R&D, regulatory management, and commercial development

Echocardiography

Author: Petros Nihoyannopoulos
Publisher: Springer Science & Business Media
ISBN: 9781848822931
Format: PDF, Mobi
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As increasing emphasis is placed on evidence-based medicine and the need to a rapid and clinically effective diagnosis of cardiac disease, so echocardiography is ever-more present at the forefront of cardiology. This book represents the current knowledge in the technique of cardiology and is designed to guide the resident and fellow through the most common applications of echocardiography while touching on some of the less often seen echocardiographic diagnoses.

Blood Compatible Materials and Devices

Author: Michael Szycher
Publisher: CRC Press
ISBN: 9780877627333
Format: PDF, ePub, Mobi
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With the goal of stimulating the fundamental thought process among graduate students and challenging professionals in the health care industry to utilize the presented information for the introduction of improved medical devices, this volume reviews the present status of biomaterials and devices, and projects the possible pattern of research extending to the beginning of the next century. No index. Acidic paper. Annotation copyrighted by Book News, Inc., Portland, OR

Learning from Nature How to Design New Implantable Biomaterials From Biomineralization Fundamentals to Biomimetic Materials and Processing Routes

Author: Rui L. Reis
Publisher: Springer Science & Business Media
ISBN: 140202648X
Format: PDF
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The development of materials for any replacement or regeneration application should be based on the thorough understanding of the structure to be substituted. This is true in many fields, but particularly exigent in substitution and regeneration medicine. The demands upon the material properties largely depend on the site of application and the function it has to restore. Ideally, a replacement material should mimic the living tissue from a mechanical, chemical, biological and functional point of view. Of course this is much easier to write down than to implement in clinical practice. Mineralized tissues such as bones, tooth and shells have attracted, in the last few years, considerable interest as natural anisotropic composite structures with adequate mechanical properties. In fact, Nature is and will continue to be the best materials scientist ever. Who better than nature can design complex structures and control the intricate phenomena (processing routes) that lead to the final shape and structure (from the macro to the nano level) of living creatures? Who can combine biological and physico-chemical mechanisms in such a way that can build ideal structure-properties relationships? Who, else than Nature, can really design smart structural components that respond in-situ to exterior stimulus, being able of adapting constantly their microstructure and correspondent properties? In the described philosophy line, mineralized tissues and biomineralization processes are ideal examples to learn-from for the materials scientist of the future.

Valvular Heart Disease A Companion to Braunwald s Heart Disease

Author: Catherine M. Otto
Publisher: Elsevier Health Sciences
ISBN: 145575840X
Format: PDF
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Internationally renowned cardiologists Drs. Catherine M. Otto and Robert O. Bonow help you to apply all of the latest scientific knowledge and clinical strategies with Valvular Heart Disease, a companion to Braunwald’s Heart Disease. This indispensable resource for your everyday practice provides all of the knowledge you need to give your patients the most accurate diagnoses, the best possible heart disease treatment options, and the expert care they deserve. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Apply today's best medical and surgical approaches with comprehensive, expert guidance on today's full range of clinical heart disease treatments. Provide appropriate care to pediatric and pregnant patients with focused chapters on the unique needs of these special populations. Update your knowledge of these increasingly common heart diseases with brand-new chapters covering 3-dimensional anatomy of the aortic and mitral valves; clinical and genetic risk factors for calcific valve disease; risk assessment for aortic and mitral valve surgery; image-guided transcatheter valve procedures; optimal timing of valve interventions; state-of-the-art valve surgery; and much more. Apply the most current standards of practice with summaries of the ACC/AHA and new ESC valvular heart disease guidelines in each chapter. Vividly visualize heart valve anatomy and dysfunction, as well as important techniques and procedures, thanks to a multitude of detailed illustrations, full-color images, and online video content. Search the full text and access all the images online at Expert Consult.