Medicinal Chemistry

Author: Thomas Nogrady
Publisher: Oxford University Press
ISBN: 9780195104554
Format: PDF, Mobi
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Fully updated, this textbook takes a receptor-based, target-centred approach, presenting concepts central to the study of drug action in a logical, mechanistic way, grounded on molecular & biochemical principles.

Medicinal Chemistry

Author: Thomas Nogrady
Publisher: Oxford University Press
ISBN: 9780198026457
Format: PDF, Mobi
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Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.

Medicinal Chemistry

Author: Th Nogrady
Publisher: Oxford University Press, USA
ISBN: 9780195053692
Format: PDF, ePub, Mobi
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Emphasizing the molecular action of drugs, this text incorporates recent findings from biochemical pharmacology along with the latest insights into the interactions of drugs with their receptors. It is organized by targets of drug action--endogenous messengers and their receptors, membranes, enzymes, and DNA, among others--and covers all drug groups and their therapeutic applications. This new edition has been thoroughly revised to provide expanded coverage of co-transmitters and neurohormones as well as adenosine receptors and calcium channel blockers. The chapter on drug distribution and metabolism has been extended, and the final chapter on principles of drug design outlines new methods, such as numerical techniques and computer graphics. Other new topics include atrial natriuretic factors, antiarrhythmic drugs, and DNA topoisomerase inhibitory mechanism of antitumor and antibacterial agents. The text is illustrated with hundreds of formulas and tables, and the index includes an extensive listing of drugs.

The Organic Chemistry of Drug Design and Drug Action

Author: Richard B. Silverman
Publisher: Academic Press
ISBN: 0123820316
Format: PDF, Docs
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The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-π and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates

The Practice of Medicinal Chemistry

Author: Camille Georges Wermuth
Publisher: Elsevier
ISBN: 012417213X
Format: PDF, Mobi
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The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com

Quantum Medicinal Chemistry

Author: Paolo Carloni
Publisher: John Wiley & Sons
ISBN: 9783527304561
Format: PDF, Kindle
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Computational methods are transforming the work of chemical and pharmaceutical laboratories. Increasingly faster and more exact simulation algorithms have made quantum chemistry a valuable tool in the search for active substances. Written by a team of leading international quantum chemists, this book is aimed at both beginners as well as experienced users of quantum chemical methods. All commonly used quantum chemical methods are treated here, including Density Functional Theory, quantum and molecular mechanical approaches. Numerous examples illustrate the use of these methods for dealing with problems in pharmaceutical practice, whether the study of inhibitor binding, identifying the surface load of active substances or deriving molecular descriptors using quantum chemical tools. For anyone striving to stay ahead in this rapidly evolving field.

Chemistry and Molecular Aspects of Drug Design and Action

Author: E. A. Rekka
Publisher: CRC Press
ISBN: 9781420008272
Format: PDF, ePub, Mobi
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An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed. Known as rational drug design, this contemporary process is defined by three main steps: the discovery of lead compounds, surgical manipulation to develop pharmacophores, and further optimization to produce the best compounds. Chemistry and Molecular Aspects of Drug Design and Action brings together an impressive collection of world-renowned pharmacochemistry scientists who are currently defining the emergence of rational drug design. Offering insight from their own specialized research, these pioneers highlight the variety of approaches being employed in this field, including those that start by considering either molecular mechanisms of drug action, or the metabolizing enzyme action occurring in the structure of a drug molecule. Another approach they explore is one that starts from the pathobiochemistry and pathophysiology of target diseases. Furthermore, the book also considers drug development that makes use of already developed compounds stored in data banks. Divided into five parts, each dedicated to various aspects of the classical medicinal chemistry approach, the text makes it easy for readers to focus on a field of specific interest. Chemical, Biochemical, and Biological Aspects of Pathophysiological Conditions Classical Medicinal Chemistry Drug Design, Chemical and Molecular Aspects of Drug Action Drug Xenobiotic Metabolism Physical Organic and Theoretical Medicinal Chemistry While each section can be studied independently, the combined material in this volume provides the most comprehensive overview available on rational drug design. This work is an invaluable resource both for those entering the field, as well as those researchers looking to build on current progress.

Chemical and Biochemical Approaches for the Study of Anesthetic Function

Author:
Publisher: Academic Press
ISBN: 0128127414
Format: PDF, Docs
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Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part A, Volume 602 assembles new information on our understanding of anesthesia. This latest release in the series includes sections on how physical accuracy leads to biological relevance, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, pharmacophore QSAR, QM, ONIOM, and kinetic modeling of electrophysiology data. We have selected the primary experts to write about each approach This provides one-stop shopping for all the means of addressing this complex question Anesthesia is enormously important as almost everybody receives it at some point

Thermodynamics and Kinetics of Drug Binding

Author: György Keserü
Publisher: John Wiley & Sons
ISBN: 352733582X
Format: PDF
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This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors.

Medicinal chemistry

Author: Th Nogrady
Publisher: Oxford University Press, USA
ISBN:
Format: PDF, ePub, Mobi
Download Now
Emphasizing the molecular action of drugs, this text incorporates recent findings from biochemical pharmacology along with the latest insights into the interactions of drugs with their receptors. It is organized by targets of drug action--endogenous messengers and their receptors, membranes, enzymes, and DNA, among others--and covers all drug groups and their therapeutic applications. This new edition has been thoroughly revised to provide expanded coverage of co-transmitters and neurohormones as well as adenosine receptors and calcium channel blockers. The chapter on drug distribution and metabolism has been extended, and the final chapter on principles of drug design outlines new methods, such as numerical techniques and computer graphics. Other new topics include atrial natriuretic factors, antiarrhythmic drugs, and DNA topoisomerase inhibitory mechanism of antitumor and antibacterial agents. The text is illustrated with hundreds of formulas and tables, and the index includes an extensive listing of drugs.