Medicinal Natural Products

Author: Paul M. Dewick
Publisher: John Wiley & Sons
ISBN: 1119964571
Format: PDF
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Medicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine. There have been rapid advances in biosynthetic understanding over the past decade through enzymology, gene isolation and genetic engineering. Medicinal Natural Products has been extended and fully updated in this new edition to reflect and explain these developments and other advances in the field. It retains the user-friendly style and highly acclaimed features of previous editions: a comprehensive treatment of plant, microbial, and animal natural products in one volume extensive use of chemical schemes with annotated mechanistic explanations cross-referencing to emphasize links and similarities boxed topics giving further details of medicinal materials, covering sources, production methods, use as drugs, semi-synthetic derivatives and synthetic analogues, and modes of action Medicinal Natural Products: A Biosynthetic Approach, Third Edition, is an invaluable textbook for students of pharmacy, pharmacognosy, medicinal chemistry, biochemistry and natural products chemistry.

Medicinal Natural Products

Author: Paul M. Dewick
Publisher: John Wiley & Sons
ISBN: 9780471496410
Format: PDF, ePub, Mobi
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Medicinal Natural Products, Second Edition is a comprehensive guide providing information on all classes of natural products in medicine. It builds upon fundamental chemical principles and demonstrates a unique integration of plant, microbial and animal natural products in one volume. The text guides the reader through a wealth of diverse natural metabolites used in medicine with sources, production methods, use as drugs and modes of action all extensively covered. Taking a chemistry based approach it combines traditional pharmacognosy with medicinal chemistry. The structure is user-friendly and includes the acclaimed grey boxes on groups of products and detailed mechanistic explanations. * Adopts a novel biosynthetic theme rather than a traditional descriptive approach * Includes extensive further reading at the end of the chapter * Thoroughly revised and updated to incorporate comprehensive coverage of plant, microbial and animal products * Includes the latest developments in the field * New material on genetic manipulation of biosynthetic pathways and non-mevalonate pathway to terpanoids * User-friendly format including extensive use of chemical schemes with annotated mechanistic explanations

Medicinal Natural Products

Author: Paul M. Dewick
Publisher: John Wiley and Sons
ISBN: 0470742798
Format: PDF, Docs
Download Now
Medicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine. There have been rapid advances in biosynthetic understanding over the past decade through enzymology, gene isolation and genetic engineering. Medicinal Natural Products has been extended and fully updated in this new edition to reflect and explain these developments and other advances in the field. It retains the user-friendly style and highly acclaimed features of previous editions: a comprehensive treatment of plant, microbial, and animal natural products in one volume extensive use of chemical schemes with annotated mechanistic explanations cross-referencing to emphasize links and similarities boxed topics giving further details of medicinal materials, covering sources, production methods, use as drugs, semi-synthetic derivatives and synthetic analogues, and modes of action Medicinal Natural Products: A Biosynthetic Approach, Third Edition, is an invaluable textbook for students of pharmacy, pharmacognosy, medicinal chemistry, biochemistry and natural products chemistry.

Natural Product Biosynthesis

Author: Christopher T. Walsh
Publisher: Royal Society of Chemistry
ISBN: 1788010760
Format: PDF, Kindle
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Authored by leading experts in the enzymology of natural product biosynthesis, this textbook provides a thorough description of the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era. Although some 500-600,000 natural products have been isolated and characterized over the past two centuries, there may be a 10-fold greater inventory awaiting immediate exploration based on biosynthetic gene cluster predictions. The approach of this book is to codify the chemical logic that underlies each natural product structural class as they are assembled from building blocks of primary metabolism. This text will serve as a reference point for chemists of every subdiscipline, including synthetic organic chemists and medicinal chemists. It will also be valuable to bioinformatic and computational biologists, to pharmacognocists and chemical ecologists, to bioengineers and synthetic biologists.

Introduction to Natural Products Chemistry

Author: Rensheng Xu
Publisher: CRC Press
ISBN: 1439860777
Format: PDF, Kindle
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Natural products chemistry—the chemistry of metabolite products of plants, animals and microorganisms—is involved in the investigation of biological phenomena ranging from drug mechanisms to gametophytes and receptors and drug metabolism in the human body to protein and enzyme chemistry. Introduction to Natural Products Chemistry has collected the most important research results of natural product chemistry in China. It overviews the basic principles of isolation, structure, and characteristics of natural products and illustrates current research techniques of structure elucidation with real-life examples of wet chemistry and spectroscopic analyses (UV, IR, MS, and NMR, especially 2d-NMR, HMBC, and HMQC), bioactivity, biosynthesis, and chemical synthesis. Specifically, this book covers: Extraction and isolation of natural products Chemistry of fungal products Alkaloids, sesquiterpenoids, diterpenes, and saponins Amino acids and peptides Flavonoids, anthraquinones, coumarins, and lignans Marine natural products Structural modification of active principles from traditional Chinese medicine Chemical synthesis of natural products Although natural products chemistry has produced enormous results and made great contributions to human health, industry, and agriculture, only a fraction of natural resources have been rigorously studied. Chinese natural products are a gold mine for further exploration with modern technology and methods. This book represents the continuing collaboration between the fields of natural products chemistry, medicine, biology, and agriculture which will continue to discover and implement novel chemical products from natural sources.

Essentials of Organic Chemistry

Author: Paul M. Dewick
Publisher: John Wiley & Sons
ISBN: 1118681967
Format: PDF
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Essentials of Organic Chemistry is an accessible introduction to the subject for students of Pharmacy, Medicinal Chemistry and Biological Chemistry. Designed to provide a thorough grounding in fundamental chemical principles, the book focuses on key elements of organic chemistry and carefully chosen material is illustrated with the extensive use of pharmaceutical and biochemical examples. In order to establish links and similarities the book places prominence on principles and deductive reasoning with cross-referencing. This informal text also places the main emphasis on understanding and predicting reactivity rather than synthetic methodology as well as utilising a mechanism based layout and featuring annotated schemes to reduce the need for textual explanations. * tailored specifically to the needs of students of Pharmacy Medical Chemistry and Biological Chemistry * numerous pharmaceutical and biochemical examples * mechanism based layout * focus on principles and deductive reasoning This will be an invaluable reference for students of Pharmacy Medicinal and Biological Chemistry.

Comprehensive Natural Products II Chemistry and Biology

Author:
Publisher: Elsevier
ISBN: 0080453821
Format: PDF, ePub
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This work presents a definitive interpretation of the current status of and future trends in natural products—a dynamic field at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids, and enzymes. With more than 1,800 color figures, Comprehensive Natural Products II features 100% new material and complements rather than replaces the original work (©1999). Reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine Stimulates new ideas among the established natural products research community—which includes chemists, biochemists, biologists, botanists, and pharmacologists Informs and inspires students and newcomers to the field with accessible content in a range of delivery formats Includes 100% new content, with more than 6,000 figures (1/3 of these in color) and 40,000 references to the primary literature, for a thorough examination of the field Highlights new research and innovations concerning living organisms and their distinctive role in our understanding and improvement of human health, genomics, ecology/environment, and more Adds to the rich body of work that is the first edition, which will be available for the first time in a convenient online format giving researchers complete access to authoritative Natural Products content

Anticancer Agents from Natural Products Second Edition

Author: Gordon M. Cragg
Publisher: CRC Press
ISBN: 1439813825
Format: PDF, ePub, Mobi
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The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.

Greene s Protective Groups in Organic Synthesis

Author: Peter G. M. Wuts
Publisher: John Wiley & Sons
ISBN: 1118905121
Format: PDF, ePub, Docs
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An indispensable reference for any practicing synthetic organic or medicinal chemist, this book continues the tradition of Greene’s as comprehensive in the overall scope of coverage, providing the most relevant and useful examples to illustrate each methodology. • Presents valuable material, on the application of protective groups in organic chemistry, that is not easily found by casual searching • Helps chemists to plan, investigate, and carry out organic syntheses in an efficient manner • Adds over 2800 new references to update since the publication of the last edition • Reviews of the prior edition: "An essential bible for the library or personal bookshelf of chemists performing complex synthesis." (CHOICE, May 2007) "...the most up-to-date compilation available...should be an integral part of all institutional libraries...it is also highly recommended that individuals...maintain their own copy..." (Journal of Medicinal Chemistry, March 8, 2007) "...continues to be a comprehensive guide to the techniques for the formation and cleavage of protective groups." (Journal of the American Chemical Society, January 31, 2007)

Natural Product Biosynthesis by Microorganisms and Plants

Author: David A. Hopwood
Publisher: Academic Press
ISBN: 0123942918
Format: PDF, ePub, Docs
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This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The second of 3 volumes covering Natural product biosynthesis by microorganisms and plants. This new volume continues the legacy of this premier serial Contains quality chapters authored by leaders in the field The second of 3 volumes it has chapters on such topics as biological chlorination, bromination and iodination, and phylogenetic approaches to natural product structure prediction